Endocrine Abstracts

Introduction: Thyroid dysfunction has been described as a common clinical entity in HIV infected patients, commonly with negative autoimmune tests. The aim of this work was to determine the prevalence of thyroid abnormalities in a cohort of HIV-infected males in a stable clinical state, the effect of exposure to ART on thyroid function and to identify the risk factors.Materials and methods: This is a cross-sectional, observational study of 90 HIV infecte...

Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function.We tested whether hyperandrogenic insulin-resistant women with PCOS, who have an increased risk of vascular disease, display impaired leukocyte-endothelium interactions, and mitochondrial dysfunction. This was a prospective controlled study conducted in an academic medical center.The study population consisted of 43 lean reproducti...

Circulating C3 levels are elevated in obese patients, but how this factor is affected after weight loss through diet is a question that is yet unanswered. Therefore, the aim of this study was to evaluate the effects of weight loss on lipid and hydrocarbonated metabolism parameters and on the levels of C3 and C4 components of complement in obese patients. This is a longitudinal intervention study based on a 6 week very low calorie diet (VLCD), a liquid formula of 603 kcal/day. ...

Introduction: Cross-sex hormone treatment (CHT) in male-to-female (M2F) transsexuals affects the hemostatic balance, with the emergence of a prothrombotic state with the use of certain estrogen (oral ethinyl estradiol vs 17β estradiol). Testosterone administration to F2M transsexuals had an antithrombotic effect. In female-to-male in (F2M) transsexuals administration of testosterone seems to carry a mild antithrombotic effect.Objective: To quantify ...

Introduction: Hyponatremia is the most common electrolyte disorder in hospitalized patients. SIADH is characterized by euvolemic hyponatremia with sodium and urine osmolality inappropriately high. The selective antagonist of the vasopressin V2 receptor (tolvaptan) helps to eliminate water free of solute (aquaresis), being effective in treating this condition.Objetive: Evaluate the efficacy and safety of tolvaptan in the treatment of SIADH.<p class="a...